Group members
Richard Lundmark, PhD, PI (2008-present)
Richard is professor in histology and cell biology with an particular interest in the mechanisms for generation of small lipid membrane vesicles.
Elin Larsson, PhD, Labmanager (2012-present)
Elin is a biochemist and cell biologist working on protein complexes that stabilise caveolae to the cell surface. She is also labmanager of the Lundmark lab.
Wai Lok Yau, post doc (2020-present)
Lok is a virologist and cell biologist working on how host proteins influence virus replication compartment in cells.
Sebastian Rönfeldt, post doc (2021-present
Sebastian is an expert in correlative light and electron microscopy working on the mechanism for uptake of free fatty acids in cells.
Lauri Pulkkinen, post doc (2022-present)
Lauri is a structural virologist working on mechanisms for how virus proteins interact and remodel cellular membranes.
Bianca Korse, master student
Bianca is a biomedicine student working on the structure of membrane assembled protein oligomeres.
Previous group members
Björn Morén, PhD
Björn was the first PhD student in the lab and he defended his thesis in 2014: "Caveolae associated proteins and how they effect caveolae dynamics”
He also came back to work on fatty acid uptake using advanced microscopy analysis 2022-2023
Doherty GJ, Åhlund MK, Howes M, Morén B, Parton RG, McMahon HT, Lundmark R; The endocytic protein GRAF1 is directed to cell matrix adhesion sites and regulates cell spreading. Molecular Biology of the Cell, 22, 4380-9 (2011).
Morén B, Shah C, Howes MT, Schieber NL, McMahon HT, Parton RG, Daumke O, Lundmark R; EHD2 regulates caveola dynamics via ATP-driven targeting and oligomerization. Molecular Biology of the Cell, 23, 1316-29 (2012).
Shah C, Hegde B, Morén B, Behrmann E, Mielke T, Moenke G, Spahn C, Richard Lundmark R, Daumke O, Ralf Langen R; Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2. Structure, 22, 409-20 (2014).
Mohan J, Morén B, Larsson E, Holst MR, Lundmark R; Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae. Journal of Cell Science, 128, 979-91 (2015).
Morén B, Hansson B, Lundmark R, Göransson O, Stenkula KG; EHD2 regulates adipocyte function and is enriched at cell surface-associated lipid droplets in primary human adipocytes. Molecular Biology of the Cell, 30, 1147-59, doi: 10.1091/mbc.E18-10-0680 (2019).
Larsson E, Morén B, McMahon KA, Parton RG, Lundmark R; Dynamin2 functions as an accessory protein to reduce the rate of caveola internalization. J Cell Biol. Apr 3;222(4):e202205122. doi: 10.1083/jcb.202205122. Epub 2023 Feb 2.PMID: 36729022 (2023)
Monica Åhlund, PhD
Monica was a PhD student in the lab and she defended her thesis in 2015: “Regulation of GRAF1 membrane sculpting function during cell movement”
Doherty GJ, Åhlund MK, Howes M, Morén B, Parton RG, McMahon HT, Lundmark R; The endocytic protein GRAF1 is directed to cell matrix adhesion sites and regulates cell spreading. Molecular Biology of the Cell, 22, 4380-9 (2011).
Francis MK, Holst MR, Vidal-Quadras M, Henriksson S, Sandblad L and Lundmark R; Endocytic membrane turnover at the leading edge is driven by a transient interaction between Cdc42 and GRAF1. Journal of Cell Science, 128, 4183-95 (2015).
Rompikuntal PK, Vdovikova S, Duperthuy M, Johnson TL, Monika Åhlund M, Lundmark R, Oscarsson J, Sandkvist M, Uhlin BE, Wai SN; Outer membrane vesicle-mediated export of processed PrtV protease from Vibrio cholera; PLOS one, 10(7) (2015).
Vidal-Quadras M, Holst M, R, Francis M, K, Larssson E, Hachimi M, Yau W, L, Peränen J, Martín-Belmonte F and Lundmark R; Endocytic turnover of Rab8 controls cell polarization; Journal of Cell Science, 130, 1147-1157. (2017).
Vdovikova S, Luhr M, Szalai P, Nygård Skalman L, Francis MK, Lundmark R, Engedal N, Johansson J, Nyunt Wai S; A novel role of Listeria monocytogenes membrane vesicles in inhibition of autophagy and cell death. Frontiers in Cellular and Infection Microbiology, 7:154. (2017).
Jagan Mohan, PhD
Jagan was a PhD student in the lab and he defended his thesis in 2016 “Regulation of assembly and cell surface dynamics of caveolae”
Mohan J, Morén B, Larsson E, Holst MR, Lundmark R; Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae. Journal of Cell Science, 128, 979-91 (2015).
Hoernke M, Mohan J, Larsson E, Blomberg J, Kahra D, Westenhoff S, Schwieger C, Lundmark R; EHD2 restrains dynamics of caveolae by an ATP‑dependent, membrane-bound, open conformation Proceedings of the National Academy of Sciences, USA,114(22), E4360-E4369 (2017).
Madlen Hubert, PhD
Madlen was a post doc in the lab working on the role of lipids in regulating biogenesis and surface stability of caveolae.
Hubert M, Larsson E, Vegesna GNV, Ahnlund M, Johansson AI, Moodie LWK and Lundmark R; “Lipid accumulation controls the balance between surface connection and scission of caveolae” eLife Accepted (2020).
Hubert M, Larsson E and Lundmark R; Keeping in touch with the membrane; protein- and lipid-mediated confinement of caveolae to the cell surface. Biochemical Society Transactions. Accepted. invited peer-reviewed. (2020).
Larsson E, Hubert M, Lundmark R. Analysis of protein andlipidinteractions using liposome co-sedimentation assays. Methods Mol Biol. 2020;2169:119-127. doi: 10.1007/978-1-0716-0732-9_11. PMID: 32548824
Rodrigues L, Schneider F, Zhang X, Larsson E, Moodie L, Dietz H, Papadakis CM, Gerhard Winter G, Lundmark R, Hubert M; Cellular uptake of self-assembled phytantriol-based hexosomes is independent of major endocytic machineries. Journal of Colloid and interphase science, 553, 820-833. doi: 10.1016/j.jcis.2019.06.045. (2019)
Holst MR, Vidal-Quadras M, Larsson E, Song J, Hubert M, Blomberg J, Lundborg M, Landström M and Lundmark R; Clathrin-independent endocytosis suppresses cancer cell blebbing and invasion. Cell Reports, 20, 1893-1905, (2017).
Moodie LWK, Hubert M, Zhou X, Albers MF, Lundmark R, Wanrooij S and Christian Hedberg; Photoactivated Colibactin Probes Induce Cellular DNA Damage. Angewandte Chemie international edition, 58, 1417-22, doi: 10.1002/ange.201812326, (2019).
Ngyuen din Van, PhDK
Ken was a post doc in the lab working on the biogenesis of TBEV replication compartments
Yau WL, Nguyen-Dinh V, Larsson E, Lindqvist R, Överby AK, Lundmark R; Model System for the Formation of Tick-Borne Encephalitis Virus Replication Compartments without Viral RNA Replication. Journal of Virology, Jun 26, JVI.00292-19. doi: 10.1128/JVI.00292-19, (2019)
Maria Vidal-Quadras, PhD
Maite was a post doc in the lab working on the coupling between endo- and exocytosis and its impact on cell polarity
Francis MK, Holst MR, Vidal-Quadras M, Henriksson S, Sandblad L and Lundmark R; Endocytic membrane turnover at the leading edge is driven by a transient interaction between Cdc42 and GRAF1. Journal of Cell Science, 128, 4183-95 (2015).
Vidal-Quadras M, Holst M, R, Francis M, K, Larssson E, Hachimi M, Yau W, L, Peränen J, Martín-Belmonte F and Lundmark R; Endocytic turnover of Rab8 controls cell polarization; Journal of Cell Science, 130, 1147-1157. (2017).
Holst MR, Vidal-Quadras M, Larsson E, Song J, Hubert M, Blomberg J, Lundborg M, Landström M and Lundmark R; Clathrin-independent endocytosis suppresses cancer cell blebbing and invasion. Cell Reports, 20, 1893-1905, (2017).
Lars Nygård-Skalman, PhD
Lars was a PhD student in the lab and she defended his thesis in 2017: “Pathogen entry mechanisms and endocytic responses to plasma membrane damage”
Olofsson A1, Nygård Skalman L1, Ikenna O, Lundmark R, and Arnqvist A; Uptake of Helicobacter pylori vesicles is facilitated by clathrin-dependent and clathrin-independent endocytic pathways; mBio, 5, e00979-14 (2014) 1 These authors contributed equally to this work.
Storm RJ, Persson BD, Nygård Skalman L, Frängsmyr L, Lindström M, Rankin G, Lundmark R, Pedrosa Domellöf F, Arnberg N; Human adenovirus type 37 uses αVβ1 and α3β1 integrins for infection of human corneal cells. Journal of Virology, 91(5) (2017).
Vdovikova S, Luhr M, Szalai P, Nygård Skalman L, Francis MK, Lundmark R, Engedal N, Johansson J, Nyunt Wai S; A novel role of Listeria monocytogenes membrane vesicles in inhibition of autophagy and cell death. Frontiers in Cellular and Infection Microbiology, 7:154. (2017).
Vonderstein K, Nilsson E, Hubel P, Nygård Skalman L, Upadhyay A, Pasto J, Andreas Pichlmair A, Lundmark R, and Överby A; Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles. Journal of Virology, 92. JVI.01751-17. (2017).
Nygard-Skalman L, Holst MR, Larsson E, Lundmark R; Plasma membrane damage caused by Listeriolysin O is not repaired through endocytosis of the membrane pore. Biology Open, 7, doi: 10.1242/bio.03528, (2018).
Mikkel Roland Holst, PhD
Mikkel was a post doc in the lab working on the protein GRAF1 and its role in generating an endocytic membrane reservoir in response to altered membrane tension.
Mohan J, Morén B, Larsson E, Holst MR, Lundmark R; Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae. Journal of Cell Science, 128, 979-91 (2015).
Francis MK, Holst MR, Vidal-Quadras M, Henriksson S, Sandblad L and Lundmark R; Endocytic membrane turnover at the leading edge is driven by a transient interaction between Cdc42 and GRAF1. Journal of Cell Science, 128, 4183-95 (2015).
Vidal-Quadras M, Holst M, R, Francis M, K, Larssson E, Hachimi M, Yau W, L, Peränen J, Martín-Belmonte F and Lundmark R; Endocytic turnover of Rab8 controls cell polarization; Journal of Cell Science, 130, 1147-1157. (2017).
Holst MR, Vidal-Quadras M, Larsson E, Song J, Hubert M, Blomberg J, Lundborg M, Landström M and Lundmark R; Clathrin-independent endocytosis suppresses cancer cell blebbing and invasion. Cell Reports, 20, 1893-1905, (2017).
Daste F*, Walrant A*, Holst MR*, Gadsby JR*, Mason J, Lee, J, Brook D, Mettlen M, Larsson E, Lee SF, Lundmark R and Gallop JL; Control of actin polymerization via the coincidence of phosphoinositides and high membrane curvature. Journal of Cell Biology, 216, 3745-3765, (2017). * These authors contributed equally to this work.
Wai Lok, PhDK
Lok was a post doc in the lab working on TBEV replication compartments. Please also note that he is now back in the lab again!
Yau WL, Nguyen-Dinh V, Larsson E, Lindqvist R, Överby AK, Lundmark R; Model System for the Formation of Tick-Borne Encephalitis Virus Replication Compartments without Viral RNA Replication. Journal of Virology, Jun 26, JVI.00292-19. doi: 10.1128/JVI.00292-19, (2019)
Vidal-Quadras M, Holst M, R, Francis M, K, Larssson E, Hachimi M, Yau W, L, Peränen J, Martín-Belmonte F and Lundmark R; Endocytic turnover of Rab8 controls cell polarization; Journal of Cell Science, 130, 1147-1157. (2017).
Sara Henriksson, PhD
Sara was a shared post doc in the lab working on correlative imaging techniques together with the Biochemical Imaging Centre
Francis MK, Holst MR, Vidal-Quadras M, Henriksson S, Sandblad L and Lundmark R; Endocytic membrane turnover at the leading edge is driven by a transient interaction between Cdc42 and GRAF1. Journal of Cell Science, 128, 4183-95 (2015).
Agnieszka Pastula, PhD
Agnieszka was a post doc who established an organoid workflow in the lab and focused her work on the role of GRAF1 in gastro-intestinal cancer andepithelial to mesenchymal transition.
Pastuła A, Lundmark R; Induction of Epithelial-mesenchymal Transition in MDCK II Cells Bio Protoc. Feb 5;11(3):e3903. doi: 10.21769/BioProtoc.3903. eCollection 2021 Feb 5. PMID: 33732790. (2021)
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Ankita Shukla, PhD
Ankita was a post doc in the lab working on membrane interaction and structure of the TBEV protein NS1
Hudson Pace, PhD
Hudson was a post doc in the lab working on supported lipid bilayers and composition of the caveolae coat.
Liu K-C, Pace H, Larsson E, Hossain S, Kabedev A, Shukla A, Jerschabek V, Mohan J, Bergström C AS, Bally M, Schwieger C, Hubert M and Lundmark R; Membrane insertion mechanism of the caveola coat protein Cavin1. Proceedings of the National Academy of Sciences, USA. Jun 21;119(25):e2202295119. doi: 10.1073/pnas.2202295119. Epub 2022 Jun 13. PMID: 35696574 (2022)
Kang Cheng Liu, PhD
Kang was a post doc in the lab working on membrane interaction and structure of the caveolae coat protein Cavin1
Liu K-C, Pace H, Larsson E, Hossain S, Kabedev A, Shukla A, Jerschabek V, Mohan J, Bergström C AS, Bally M, Schwieger C, Hubert M and Lundmark R; Membrane insertion mechanism of the caveola coat protein Cavin1. Proceedings of the National Academy of Sciences, USA. Jun 21;119(25):e2202295119. doi: 10.1073/pnas.2202295119. Epub 2022 Jun 13. PMID: 35696574 (2022)